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Common side effects include nausea and loss of appetite. [6] Other side effects include liver inflammation, methemoglobinemia, [7] and a number of types of skin rashes. [4] While the safety of use during pregnancy is not entirely clear some physicians recommend that it be continued in those with leprosy. [4] It is of the sulfone class. [4]
It is metabolized in human hepatocytes and human microsomes to form [2-(2',6'-dichloro-4'-hydroxy- phenylamino) phenyl] acetoxyacetic acid as the major metabolite, which is then further conjugated. According to the Biopharmaceutical Classification System (BCS) drug substances are classified to four classes upon their solubility and permeability.
Age, bone type, drug therapy and pre-existing bone pathology are factors that affect healing. The role of bone healing is to produce new bone without a scar as seen in other tissues which would be a structural weakness or deformity. [2] The process of the entire regeneration of the bone can depend on the angle of dislocation or fracture.
Traction involves using a pulling force to align bones and reduce fractures, particularly in cases involving the spine, pelvis, or long bones. It can be achieved through a variety of mechanisms, including skin traction (using adhesive materials attached to the skin) or skeletal traction (which involves pins or wires placed directly into the bone).
The head rests on the top part of the vertebral column, with the skull joining at C1 (the first cervical vertebra known as the atlas).The skeletal section of the head and neck forms the top part of the axial skeleton and is made up of the skull, hyoid bone, auditory ossicles, and cervical spine.
Hydrocolloid dressings are used to treat uninfected wounds. [6] Dressings may be used, under medical supervision, even where aerobic infection is present; the infection should be treated appropriately. [citation needed] The dressing is applied to a cleaned wound. Hydrocolloid patches are sometimes used on the face for acne.
Palatine bone; Palatine process of maxilla; Palatomaxillary suture; Paranasal sinuses; Parasphenoid; Parietal eminence; Perpendicular plate of ethmoid bone; Perpendicular plate of palatine bone; Petro-occipital fissure; Petrosal process; Petrosquamous suture; Petrous part of the temporal bone; Pharyngeal tubercle; Posterior clinoid processes ...
The exact mechanism of action of silicone gel sheeting has not been fully studied. Currently, many proposed mechanisms explain the efficacy of such treatment, including the occlusion and hydration effect, increased body surface temperature, polarized electric charge, immunological effects, etc. [9] The occlusion and hydration effect is the most studied mechanism of action.