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Yohimbine (/ joʊˈhɪmbiːn /), [2] also known as quebrachine, is an indole alkaloid derived from the bark of the African tree Pausinystalia johimbe; also from the bark of the unrelated South American tree Aspidosperma quebracho-blanco. Yohimbine is an α 2 -adrenergic receptor antagonist, and has been used in a variety of research projects.
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It is the first receptor in humans known to play a role in hair growth. [ 103 ] [ 104 ] [ 105 ] Researchers found that disruption of the gene SOX21 in mice caused cyclical hair loss. Research has suggested SOX21 as a master regulator of hair shaft cuticle differentiation, with its disruption causing cyclical alopecia in mice models. [ 106 ]
Yohimbe is one of a number of Corynanthe evergreen species growing in West and Central Africa in lowland forests. The tree grows about 30m tall, with a straight bole that is rarely larger than 50–60 cm in diameter. The bark is grey to reddish-brown, with longitudinal fissures, easy to peel and bitter-tasting. The inner bark is pinkish and ...
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