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Antidepressants may be modestly helpful for treating people who have both depression and alcohol dependence, however, the evidence supporting this association is of low quality. [68] Bupropion is used to help people stop smoking. Antidepressants are also used to control some symptoms of narcolepsy. [69]
A 2018 analysis of 21 antidepressants found them to be fairly similar overall. [29] It found tentative evidence for mirtazapine being in the more effective group and middle in tolerability. [29] After one week of usage, mirtazapine was found to have an earlier onset of action compared to selective serotonin reuptake inhibitors. [24] [30]
Studies found that in autopsies (which do not necessarily reflect living people), people with bipolar disorder had increased G-protein coupling compared to people without bipolar disorder. [107] Lithium treatment alters the function of certain subunits of the dopamine associated G-protein, which may be part of its mechanism of action.
Sertraline, sold under the brand name Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [ 10 ] The effectiveness of sertraline for depression is similar to that of other antidepressants, and the differences are mostly confined to side effects. Sertraline is better tolerated than the older ...
Based on a 2019 review, though, researchers found that if taken alongside certain prescribed antidepressants, 5-HTP supplements may potentially boost the effectiveness of those antidepressants ...
Trazodone, sold under many brand names, [1] is an antidepressant medication, [20] used to treat major depressive disorder, anxiety disorders, and insomnia. [20] It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class.
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