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These are achieved at lower doses, because many synthetic cannabinoids are more potent than marijuana, and users are often unaware of exactly what they are getting and how potent it is. [55] For example, Δ 9-THC has an EC 50 of 250 nM at CB 1 and 1157 nM at CB 2, whereas PB-22 has an EC 50 of 5.1 nM at CB 1 and 37 nM at CB 2. [8]
Hexahydrocannabinol (HHC) is a hydrogenated derivative of tetrahydrocannabinol (THC). It is a naturally occurring phytocannabinoid that has rarely been identified as a trace component in Cannabis sativa, [1][2] but can also be produced synthetically by firstly acid cyclization of cannabidiol and then hydrogenation of tetrahydrocannabinol.
Like Δ 9-THC, 11-hydroxy-THC is a partial agonist at the cannabinoid receptor CB 1, but with significantly higher binding affinity (K i = 0.37 nM compared to Δ 9-THC K i = 35 nM). [7] With respect to cAMP inhibition at CB 1 it displays a similar efficacy to that of Δ 9 -THC (EC 50 = 11 nM vs. EC 50 = 5.2 nM, respectively), but a lower ...
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Because these products are often confused for other snacks and candy, and they can be particularly potent, children can ingest significantly high amounts of THC, which can lead to severe effects.
A cannabis-infused drink is a drink infused with THC and can be as potent as a cannabis-infused food. [33] Jamie Evans, author of Cannabis Drinks, holds a cannabis-infused cocktail. In U.S. states that have legalized cannabis for recreational use, drinks were about 4% of the cannabis market in 2014 but had fallen to around 1.5% of the market in ...
“Marijuana in the 60s, 70s, 80s and early 90s was about 2% to 3% THC,” said Thurstone, who has tracked the rise of high-potency THC products in smoke shops and dispensaries.
Comparison of phytocannabinoids. Cannabinoids (/ kəˈnæbənɔɪdzˌ ˈkænəbənɔɪdz /) are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. [1][2] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in ...