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Thiamazole, also known as methimazole, is a medication used to treat hyperthyroidism. [2] This includes Graves disease, toxic multinodular goiter, and thyrotoxic crisis. [2] It is taken by mouth. [2] Full effects may take a few weeks to occur. [3] Common side effects include itchiness, hair loss, nausea, muscle pain, swelling, and abdominal ...
Topical methimazole is easier to apply for owners but more expensive than oral methimazole. [2] Between 10–25% of cats receiving methimazole will have mild side effects. These usually develop within the first 4–8 weeks and rarely develop beyond this. The most common side effects are anorexia, emesis, and lethargy.
Drug therapy is the least expensive option, even though the drug must be administered daily for the remainder of the cat's life. Carbimazole is only available as a once daily tablet. Methimazole is available as an oral solution, a tablet, and compounded as a topical gel that is applied using a finger cot to the hairless skin inside a cat's ear ...
Therapeutic drug monitoring (TDM) is a branch of clinical chemistry and clinical pharmacology that specializes in the measurement of medication levels in blood. Its main focus is on drugs with a narrow therapeutic range , i.e. drugs that can easily be under- or overdosed. [ 1 ]
Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T 3 and T 4 . It is on the World Health Organization's List of Essential Medicines.
The most common drugs in this class are thioamides, which include propylthiouracil, methimazole and its prodrug carbimazole. Additionally, propylthiouracil may reduce the de-iodination of thyroxine (T 4) into triiodothyronine (T 3) in peripheral tissues. [2] Lugol's iodine is used to temporarily block thyroid hormone synthesis before surgeries. [3]
Postmarketing surveillance (PMS), also known as post market surveillance, is the practice of monitoring the safety of a pharmaceutical drug or medical device after it has been released on the market and is an important part of the science of pharmacovigilance.
Orbital imaging is an integral tool for the diagnosis of Graves' ophthalmopathy and is useful in monitoring patients for progression of the disease. It is, however, not warranted when the diagnosis can be established clinically. Ultrasonography may detect early Graves' orbitopathy in patients without clinical orbital findings.
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