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In 2005, the Government Accountability Office (GAO) examined the change in US drug retail prices from January 2000 through December 2004 and found the average usual and customary (U&C) prices for a 30-day supply of 96 drugs frequently used by people enrolled in BlueCross BlueShield Federal Employee Programs had increased 24.5%. The average U&C ...
Levetiracetam has not been found to be useful for treatment of neuropathic pain, [26] nor for treatment of essential tremors. [27] Levetiracetam has not been found to be useful for treating all developmental disorders within the autism spectrum; [28] [29] studies have only proven to be an effective treatment for partial, myoclonic, or tonic-clonic seizures associated with autism spectrum disorder.
[29] [30] In Germany, UCB was unable to demonstrate an additional benefit in 2016, [ 31 ] 2018 [ 32 ] and 2022 [ 33 ] by adding brivaracetam. In Germany, newly approved drugs with new active ingredients have to be evaluated by the Federal Joint Committee (Germany) (Gemeinsamer Bundesausschuss) if the pharmaceutical manufacturer wishes to ...
One 1992 study stated that 26% of American supermarket retailers pursued some form of EDLP, meaning that the other 74% promoted high-low pricing strategies. [2]A 1994 study of an 86-store supermarket grocery chain in the United States concluded that a 10% EDLP price decrease in a category increased sales volume by 3%, while a 10% high-low price increase led to a 3% sales decrease.
It can be used at a dosage of up to 500 mg four times per day (2,000 mg/day). [ 1 ] [ 8 ] It is used as an aromatase inhibitor to inhibit peripheral estrogen production by mouth at a dosage of 125 mg twice per day (250 mg/day total), without significant suppression of adrenal steroidogenesis at this dosage. [ 17 ]
[30] [31] Of those with brain tumors, almost 30% have epilepsy, making them the cause of about 4% of cases. [72] The risk is greatest for tumors in the temporal lobe and those that grow slowly. [72] Other mass lesions such as cerebral cavernous malformations and arteriovenous malformations have risks as high as 40–60%. [72]
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