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Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. [1] It has been found to trigger dopamine release in the nucleus accumbens of rats. [ 2 ]
Galega officinalis (French lilac) was used in diabetes treatment for centuries. [5] In the 1920s, guanidine compounds were discovered in Galega extracts. Animal studies showed that these compounds lowered blood glucose levels.
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6-MBPB, also known as 6-(2-methylaminobutyl)benzofuran (6-MABB), is a monoamine releasing agent (MRA) and entactogen-like drug of the amphetamine, phenylisobutylamine, and benzofuran families.
[2] [3] However, ENAP is unusual in being a partial releaser of serotonin and dopamine and a full releaser of norepinephrine. [ 1 ] [ 2 ] [ 3 ] The EC 50 Tooltip half-maximal effective concentration ( E max Tooltip maximal efficacy ) values of ENAP in terms of monoamine release induction are 12 nM (66%) for serotonin, 46 nM (78%) for dopamine ...
It acts as a serotonin 5-HT 2A receptor agonist, serotonin 5-HT 2B receptor antagonist, and also interacts with other serotonin receptors, such as the serotonin 5-HT 1F receptor (agonist), 5-HT 2C receptor (very weak partial agonist or antagonist), and 5-HT 6 receptor (agonist).
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