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Ectopic fat is the storage of triglycerides in tissues other than adipose tissue, that are supposed to contain only small amounts of fat, such as the liver, skeletal muscle, heart, and pancreas. [1] This can interfere with cellular functions and hence organ function and is associated with insulin resistance in type-2 diabetes. [ 46 ]
A brown fat cell. Yellow adipose tissue in paraffin. White fat cells contain a single large lipid droplet surrounded by a layer of cytoplasm, and are known as unilocular. The nucleus is flattened and pushed to the periphery. A typical fat cell is 0.1 mm in diameter [2] with some being twice that
Chylomicron structure ApoA, ApoB, ApoC, ApoE (apolipoproteins); T (triacylglycerol); C (cholesterol); green (phospholipids). Chylomicrons transport lipids absorbed from the intestine to adipose, cardiac, and skeletal muscle tissue, where their triglyceride components are hydrolyzed by the activity of the lipoprotein lipase, allowing the released free fatty acids to be absorbed by the tissues.
Due to their hydrophobic nature, lipids and lipid digestive derivatives must be transported in the globular form within the cell, blood, and tissue spaces. The formation of a fat globule starts within the membrane bilayer of the endoplasmic reticulum. It starts as a bud and detaches from the ER membrane to join other droplets.
In adipocytes, lipid bodies tend to be larger and they may compose the majority of the cell, while in other cells they may only be induced under certain conditions and are considerably smaller in size. Lro1 is a type II integral membrane protein. The N-terminal domain facing the cytoplasm or nucleoplasm and containing a short basic region (RKRR).
The classic population of brown fat cells and muscle cells both seem to be derived from the same population of stem cells in the mesoderm, paraxial mesoderm. Both have the intrinsic capacity to activate the myogenic factor 5 (Myf5) promoter, a trait only associated with myocytes and this population of brown fat. Progenitors of traditional white ...
Peroxisomes are small (0.1–1 μm diameter) subcellular compartments (organelles) with a fine, granular matrix and surrounded by a single biomembrane which is located in the cytoplasm of a cell. [ 13 ] [ 14 ] Compartmentalization creates an optimized environment to promote various metabolic reactions within peroxisomes required to sustain ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 24 February 2025. Esters of fatty acid or triglycerides This article is about the type of nutrient in food. For fat in animals, see Adipose tissue. For chemistry of fats, see triglyceride. For other uses, see Fat (disambiguation). Idealized representation of a molecule of a typical triglyceride, the main ...