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Buruli ulcer (/ b ə ˈ r uː l i /) [2] is an infectious disease characterized by the development of painless open wounds. The disease is limited to certain areas of the world, most cases occurring in Sub-Saharan Africa and Australia.
The Global Buruli Ulcer Initiative (GBUI) is a World Health Organization (WHO) initiative to coordinate global efforts to control Buruli ulcer, [1] an infectious disease characterized by the development of painless open wounds. [2]
Mycolactone is a polyketide-derived macrolide produced and secreted by a group of very closely related pathogenic mycobacteria species including M. ulcerans, M. liflandii (an unofficial designation), M. pseudoshottsii, and some strains of M. marinum.
The bacteria can infect humans and some other animals, causing persistent open wounds called Buruli ulcer. M. ulcerans is closely related to Mycobacterium marinum, from which it evolved around one million years ago, and more distantly to the mycobacteria which cause tuberculosis and leprosy.
Deep ulcers can cause scarring of muscles and tendons, resulting in permanent disability. Buruli ulcer is caused by skin infection with bacteria called Mycobacterium ulcerans . The mechanism by which M. ulcerans is transmitted from the environment to humans is not known, but may involve the bite of an aquatic insect or the infection of open wounds.
Cat scratch disease (cat scratch fever, English–Wear infection, inoculation lymphoreticulosis, ... Buruli ulcer (Bairnsdale ulcer, Searl ulcer, Searle's ulcer) ...
Tropical ulcer, more commonly known as jungle rot, is a chronic ulcerative skin lesion thought to be caused by polymicrobial infection with a variety of microorganisms, including mycobacteria. It is common in tropical climates .
In January 2024, an Australian research group proved that Mycobacterium ulcerans, the causative pathogen of Buruli ulcer is transmitted by mosquitoes. This is the first described mosquito-borne transmission of a bacterial disease. [4]