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Cardiac allograft vasculopathy (CAV) is a progressive type of coronary artery disease in people who have had a heart transplant. [1] As the donor heart has lost its nerve supply there is typically no chest pain, and CAV is usually detected on routine testing. [2]
Endomyocardial biopsy (EMB) is an invasive procedure used routinely to obtain small samples of heart muscle, primarily for detecting rejection of a donor heart following heart transplantation. It is also used as a diagnostic tool in some heart diseases .
Margaret E. Billingham (née Macpherson) (September 20, 1930 - July 14, 2009) was a pathologist at Stanford University Medical Center, who made significant achievements in the early recognition and grading of transplant rejection following cardiac transplantation, known as 'Billingham's Criteria'.
A beating heart awaiting transplant. American medical researcher Simon Flexner was one of the first people to mention the possibility of heart transplantation. In 1907, he wrote the paper "Tendencies in Pathology," in which he said that it would be possible one day by surgery to replace diseased human organs – including arteries, stomach, kidneys and heart.
Heart Failure: The single ventricle must support both systemic and pulmonary circulation, which can lead to heart failure if demands exceed functional capacity. [ 30 ] Arrhythmias: Abnormal heart rhythms can occur due to the congenital defect or secondary to manipulation of cardiac tissue during surgery.
Reperfusion therapy is a medical treatment to restore blood flow, either through or around, blocked arteries, typically after a heart attack (myocardial infarction (MI)). Reperfusion therapy includes drugs and surgery. The drugs are thrombolytics and fibrinolytics used in a process called thrombolysis.
The patient is put on a cardiopulmonary bypass machine, also known as the heart–lung machine. This machine breathes for the patient and pumps their blood around their body while the surgeon replaces the heart valve. [citation needed] Once on cardiopulmonary bypass, the patient's heart is stopped (cardioplegia). This can be done with a Y-type ...
In 1984, he performed the world’s first successful paediatric heart transplant. [30] 1994–1995: John Wallwork: Wallwork performed the world's first heart-lung and liver transplant with Sir Roy Calne in 1986. [31] 1995–1996: Sharon Hunt: Pioneered work on post-operative care of heart transplant patients. [32] 1996–1997: William Baumgartner
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