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Simplified control circuit of human thermoregulation. [8]The core temperature of a human is regulated and stabilized primarily by the hypothalamus, a region of the brain linking the endocrine system to the nervous system, [9] and more specifically by the anterior hypothalamic nucleus and the adjacent preoptic area regions of the hypothalamus.
Occludin also plays an important role in the apoptosis. The C-terminus of occludin is important in receiving and transmitting cell survival signals. In standard cells, loss or disruption of occludin and other tight junction proteins leads to initiation of apoptosis through extrinsic pathways. [25]
This is called the precapillary sphincter. The precapillary sphincter has now also been found in the brain , where it regulates blood flow to the capillary bed. [ 3 ] The sphincter can open and close the entrance to the capillary, by which contraction causes blood flow in a capillary to change as vasomotion occurs.
The hypothalamus has a central neuroendocrine function, most notably by its control of the anterior pituitary, which in turn regulates various endocrine glands and organs. Releasing hormones (also called releasing factors) are produced in hypothalamic nuclei then transported along axons to either the median eminence or the posterior pituitary ...
Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different. A thermoconforming organism, by contrast, simply adopts the surrounding temperature as its own body temperature, thus avoiding the need for internal thermoregulation.
Sweat glands are used to regulate temperature and remove waste by secreting water, sodium salts, and nitrogenous waste (such as urea) onto the skin surface. [ 30 ] [ 46 ] The main electrolytes of sweat are sodium and chloride , [ 47 ] though the amount is small enough to make sweat hypotonic at the skin surface. [ 48 ]
Light-activated proteins: channels, pumps and enzymes. The hallmark of optogenetics therefore is introduction of fast light-activated channels, pumps, and enzymes that allow temporally precise manipulation of electrical and biochemical events while maintaining cell-type resolution through the use of specific targeting mechanisms.
Vasoconstriction and vasodilation are the respective constriction and dilation of blood vessels throughout the body to precisely control the flow of blood. This occurs myogenically by smooth muscle cells surrounding the vessels, metabolically by the changes in oxygen and carbon dioxide concentrations, and through local paracrine signaling. [5] [6]