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The progenitor notochord is derived from cells migrating from the primitive node and pit. [9] The notochord forms during gastrulation and soon after induces the formation of the neural plate (neurulation), synchronizing the development of the neural tube. On the ventral aspect of the neural groove, an axial thickening of the endoderm takes place.
The notochord plays an integral role in the development of the neural tube. Prior to neurulation, during the migration of epiblastic endoderm cells towards the hypoblastic endoderm, the notochordal process opens into an arch termed the notochordal plate and attaches overlying neuroepithelium of the neural plate. The notochordal plate then ...
The formation of neural tissues, the notochord, hair follicles, and eye structures arise from the ectoderm germ layer. Noggin activity in the mesoderm gives way to the formation of cartilage , bone and muscle growth, and in the endoderm noggin is involved in the development of the lungs.
The notochord extends from the base of the head to the tail; with it extend thick bands of paraxial mesoderm. [ 1 ] As the primitive streak continues to regress, somites form from the paraxial mesoderm by "budding off" rostrally as somitomeres , or whorls of paraxial mesoderm cells, compact and separate into discrete bodies.
A primary step in organogenesis for chordates is the development of the notochord, which induces the formation of the neural plate, and ultimately the neural tube in vertebrate development. The development of the neural tube will give rise to the brain and spinal cord. [1]
The neural crest is a ridge-like structure that is formed transiently between the epidermal ectoderm and neural plate during vertebrate development. Neural crest cells originate from this structure through the epithelial-mesenchymal transition, and in turn give rise to a diverse cell lineage—including melanocytes, craniofacial cartilage and bone, smooth muscle, dentin, peripheral and enteric ...
It is believed that bone morphogenic proteins, or BMPs, specify regions of growth along the dorsal-ventral axis of the mesoderm and plays a central role in formation of the intermediate mesoderm. [2] Vg1/Nodal signalling is an identified regulator of intermediate mesoderm formation acting through BMP signalling. [3]
The paraxial and other regions of the mesoderm are thought to be specified by bone morphogenetic proteins (BMPs) along an axis spanning from the center to the sides of the body. Members of the fibroblast growth factor family also play an important role, as does the Wnt pathway.