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Hydroxyproline is a major component of the protein collagen, [3] comprising roughly 13.5% of mammalian collagen. Hydroxyproline and proline play key roles for collagen stability. [4] They permit the sharp twisting of the collagen helix. [5]
Procollagen-proline dioxygenase catalyzes the following reaction: L-proline + alpha-ketoglutaric acid + O 2 → (2S, 4R)-4-hydroxyproline + succinate + CO 2. The mechanism for the reaction is similar to that of other dioxygenases, and occurs in two distinct stages: [3] In the first, a highly reactive Fe(IV)=O species is produced.
Glutamate-5-semialdehyde is a non-proteinogenic amino acid involved in both the biosynthesis and degradation of proline and arginine (via ornithine), [1] [2] as well as in the biosynthesis of antibiotics, such as carbapenems. It is synthesized by the reduction of glutamyl-5-phosphate by glutamate-5-semialdehyde dehydrogenase.
In enzymology, a [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase (EC 2.4.1.229) is an enzyme that catalyzes the chemical reaction.
In enzymology, a formimidoylglutamase (EC 3.5.3.8) is an enzyme that catalyzes the chemical reaction. N-formimidoyl-L-glutamate + H 2 O L-glutamate + formamide. Thus, the two substrates of this enzyme are N-formimidoyl-L-glutamate and H 2 O, whereas its two products are L-glutamate and formamide.
Hence, this enzyme has one substrate, trans-4-hydroxy-L-proline, and one product, cis-4-hydroxy-D-proline. This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is 4-hydroxyproline 2-epimerase.
The potential to drive up consumer prices is a particularly sensitive area for investors, who are worried about a revival in inflation causing the Federal Reserve to stop cutting interest rates.
Glutamate formimidoyltransferase is a methyltransferase enzyme which uses tetrahydrofolate as part of histidine catabolism. It catalyses two reactions: It catalyses two reactions: 5-formimidoyltetrahydrofolate + L- glutamate <=> tetrahydrofolate + N-formimidoyl-L-glutamate