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The Neuronal cell cycle represents the life cycle of the biological cell, its creation, reproduction and eventual death. The process by which cells divide into two daughter cells is called mitosis . Once these cells are formed they enter G1, the phase in which many of the proteins needed to replicate DNA are made.
In the past decade, research has shown that neuronal cell cycle reentry plays a fundamental role in the pathogenesis of AD. The cell cycle hypothesis of AD proposes that the disease is caused by aberrant re-entry of different neuronal populations into the cell division cycle, following a 2-hit hypothesis (Nagy et al. 1998).
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
In vertebrates, a neuroblast or primitive nerve cell [1] is a postmitotic cell that does not divide further, [2] and which will develop into a neuron after a migration phase. [3] In invertebrates such as Drosophila, neuroblasts are neural progenitor cells which divide asymmetrically to produce a neuroblast, and a daughter cell of varying ...
The two main neuronal classes in the cerebral cortex are excitatory projection neurons (around 70-80%) and inhibitory interneurons (around 20–30%). [2] Neurons are often grouped into a cluster known as a nucleus where they usually have roughly similar connections and functions. [ 3 ]
A neuron, neurone, [1] or nerve cell is an excitable cell that fires electric signals called action potentials across a neural network in the nervous system. They are located in the brain and spinal cord and help to receive and conduct impulses.
In a synapse, the neuron that sends the signal is the presynaptic neuron and the target cell receives that signal is the postsynaptic neuron or cell. Synapses can be either electrical or chemical. Electrical synapses are characterized by the formation of gap junctions that allow ions and other organic compound to instantaneously pass from one ...
The cell cycle is the cycle of events in a cell from one cell division to the next. The main article for this category is Cell cycle . Wikimedia Commons has media related to Cell cycle .