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The distribution of a random variable X with distribution function F is said to have a long right tail [1] if for all t > 0, [> + >] =,or equivalently ¯ (+) ¯ (). This has the intuitive interpretation for a right-tailed long-tailed distributed quantity that if the long-tailed quantity exceeds some high level, the probability approaches 1 that it will exceed any other higher level.
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
A fat-tailed distribution is a probability distribution that exhibits a large skewness or kurtosis, relative to that of either a normal distribution or an exponential distribution. [ when defined as? ] In common usage, the terms fat-tailed and heavy-tailed are sometimes synonymous; fat-tailed is sometimes also defined as a subset of heavy-tailed.
In probability theory, the tail dependence of a pair of random variables is a measure of their comovements in the tails of the distributions. The concept is used in extreme value theory . Random variables that appear to exhibit no correlation can show tail dependence in extreme deviations.
In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed. So, for example, digoxin has a half-life (or t 1 / 2 ) of 24–36 h; this means that a change in the dose will take the best part of a week to ...
Sen. Lisa Murkowski (R-Alaska) on Thursday described herself as “more of a Ronald Reagan Republican” than a “Trump Republican.” “I don’t think I’ve made any secret of the fact that I ...
The test confirmed that the suspect was the father of John Guillot III, or John Guillot Jr., Kirkegaard said. According to authorities, Guillot and Whitney did not know each other.
Bird flu has been on the rise in Washington state and one sanctuary was hit hard: 20 big cats – more than half of the facility’s population – died over the course of weeks.