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Neuromyelitis optica (NMO) is a particular disease within the NMOSD spectrum. It is characterised by optic neuritis and longitudinally extensive myelitis. In more than 80% of NMO cases, the cause is immunoglobulin G autoantibodies to aquaporin 4 , the most abundant water channel protein in the central nervous system. [5] [1] [4]
She has published extensively on pediatric demyelinating diseases including multiple sclerosis, neuromyelitis optica and MOG antibody disease. Banwell is the co-director of the Canadian Pediatric Demyelinating Disease Network, [ 1 ] the chair of the International Pediatric Multiple Sclerosis Study Group , [ 2 ] and the chair of the ...
Multiple sclerosis, Neuromyelitis optica, MOG antibody disease: B Jean Alexandre Barré: 1880 - 1967 France Guillain–Barré syndrome, Barré–Liéou syndrome, Barré test: B Henry Charlton Bastian: 1837 - 1915 United Kingdom Bastian-Bruns sign: B Diana Beck: 1900 - 1956 United Kingdom B Peter Emil Becker: 1908 - 2000 Germany Becker's ...
Some cases of aquaporin-4-seronegative neuromyelitis optica: NMO derived from an antiMOG associated encephalomyelitis, [22] Some cases of acute disseminated encephalomyelitis, specially the recurrent ones (MDEM) [25] Some cases of McDonalds-positive multiple sclerosis [24] [26] [23] [27] isolated optic neuritis or transverse myelitis [24]
The Transverse Myelitis Association is a not-for-profit international foundation dedicated to the support of children, adolescents, and adults with a spectrum of rare neuro-immune disorders including: Acute Disseminated Encephalomyelitis (ADEM), Neuromyelitis Optica Spectrum Disorder (NMOSD), Optic Neuritis (ON) and Transverse Myelitis (TM ...
Most patients are seronegative for NMO-IgG and GFAP, biomarkers for neuromyelitis optica. [3] ANA, indicative of autoimmune optic neuropathy, is also generally negative. [3] CSF can also be evaluated for oligoclonal bands typical of multiple sclerosis, which will not be present in CRION. [1]
After the discovery of anti-AQP4 auto-antibodies there are two kinds of Optic-Spinal MS (OSMS): Anti-AQP4 positive OSMS or Neuromyelitis optica; Anti-AQP4 negative OSMS, currently idiopathic, considered inside the Inflammatory demyelinating diseases of the central nervous system spectrum.
Cross later found that DTI could also be used to effectively detect spinal cord tissue injury as well in ms and neuromyelitis optica. [15] An important breakthrough that Cross and her colleagues made recently was discovering that gradient echo MRI can be used to reliably assess cortical gray matter damage, a common finding in MS patients. [ 16 ]
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