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InterPro is a database of protein families, protein domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences [2] in order to functionally characterise them.
InterPro In biochemistry and medicine , glycoprotein IIb/IIIa ( GPIIb/IIIa , also known as integrin α IIb β 3 ) is an integrin complex found on platelets . It is a transmembrane receptor for fibrinogen [ 1 ] and von Willebrand factor , and aids platelet activation .
InterPro In molecular biology , the ferric uptake regulator family is a family of bacterial proteins involved in regulating metal ion uptake and in metal homeostasis . The family is named for its founding member, known as the ferric uptake regulator or ferric uptake regulatory protein ( Fur ).
The general purpose of the Pfam database is to provide a complete and accurate classification of protein families and domains. [5] Originally, the rationale behind creating the database was to have a semi-automated method of curating information on known protein families to improve the efficiency of annotating genomes. [6]
The transmembrane cation channel superfamily was defined in InterPro and Pfam as the family of tetrameric ion channels.These include the sodium, potassium, [1] calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels.
Other homologues are predominantly expressed in skeletal muscle and the intestine and erythroid cells. In contrast, BTN2A1 and 2 and BTN3A1, 2, and 3 are widely expressed in many tissues, suggesting that the structural domains of Btn proteins may have both universal and tissue-specific functions.
A large group of two component regulator proteins appear to have the same N-terminal structure of 14 tandem repeats.These repeats show homology to members of INTERPRO and INTERPRO indicating that they are likely to form a beta-propeller.
The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone, neuropeptide, neurotransmitter, and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins.