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This link generates the permanent attachment of the progerin to the nuclear rim. In progeria, cellular damage can occur because that attachment occurs, and the nucleus is not in a normal state. Lonafarnib is an FTI, which means it can avoid this link, so progerin can not remain attached to the nucleus rim, and it now has a more normal state.
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A cataract is a cloudy area in the lens of the eye that leads to a decrease in vision of the eye. [1] [7] Cataracts often develop slowly and can affect one or both eyes. [1] Symptoms may include faded colours, blurry or double vision, halos around light, trouble with bright lights, and difficulty seeing at night. [1]
Cataract surgery is the most common application of lens removal surgery, and is usually associated with lens replacement. It is used to remove the natural lens of the eye when it has developed a cataract, a cloudy area in the lens that causes visual impairment. [4] [10] Cataracts usually develop slowly and can affect one or both eyes. [4]
You can also use padding, such as cotton pads or gauze, on blisters in high-pressure areas, like on your feet, the AAD says. Place the padding over the blister and cover with a bandage. Be sure to ...
Werner syndrome patients exhibit growth retardation, short stature, premature graying of hair, alopecia (hair loss), wrinkling, prematurely aged faces with beaked noses, skin atrophy (wasting away) with scleroderma-like lesions, lipodystrophy (loss of fat tissues), abnormal fat deposition leading to thin legs and arms, and severe ulcerations around the Achilles tendon and malleoli (around ankles).
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