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Antifungal resistance is a One Health concern, driven by multiple extrinsic factors, including extensive fungicidal use, overuse of clinical antifungals, environmental change and host factors. [1] Like resistance to antibacterials, antifungal resistance can be driven by antifungal use in agriculture.
Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. [3] The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. [4] For certain infections it is given with flucytosine. [5]
Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. [7] This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. [7] It may be given by mouth or intravenously. [7]
Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. [11] Applied to the skin it is used for fungal skin infections such as tinea , cutaneous candidiasis , pityriasis versicolor , dandruff , and seborrheic dermatitis . [ 12 ]
Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. [5] This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium. [5] It can be taken by mouth or used by injection into a vein. [5]
Fluconazole is an antifungal medication used for a number of fungal infections. [5] This includes candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and tinea versicolor. [5]
Micafungin is indicated for the treatment of candidemia, acute disseminated candidiasis, Candida peritonitis, abscesses and esophageal candidiasis.. Micafungin works by way of concentration-dependent inhibition of 1,3-beta-D-glucan synthase resulting in reduced formation of 1,3-beta-D-glucan, which is an essential polysaccharide comprising one-third of the majority of Candida spp. cell walls.
Echinocandin B. Echinocandins are a class of antifungal drugs [1] that inhibit the synthesis of β-glucan in the fungal cell wall via noncompetitive inhibition of the enzyme 1,3-β glucan synthase.
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