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Amlodipine-association edema can be avoided by adding ACE inhibitors or angiotensin II receptor antagonist. [10] Of the other dose-dependent side effects, palpitations (4.5% at 10 mg vs. 0.6% in placebos) and flushing (2.6% vs. 0%) occurred more often in women; dizziness (3.4% vs. 1.5%) had no sex bias. [7]
Peripheral edema is edema (accumulation of fluid causing swelling) ... Some medicines (e.g. amlodipine, pregabalin) may also cause or worsen the condition. [4]
It can also occur in patients with increased hydrostatic venous pressure or decreased oncotic venous pressure, due to obstruction of lymphatic or venous vessels draining the lower extremity. Certain drugs (for example, amlodipine) can cause pedal edema. Cerebral edema is extracellular fluid accumulation in the brain. [1]
An imbalance can cause fluid overload in the spaces between cells or tissues, which can lead to edema, per the National Institutes of Health. Edema refers to the swelling that happens when the ...
Angioedema presents itself as an abrupt onset of non-pitting, non-itchy swelling that involves the mucosal layers.Some common locations of angioedema are the face, particularly the lips and around the eyes, hands and feet, and genitalia. [2]
CCBs are particularly effective against large vessel stiffness, one of the common causes of elevated systolic blood pressure in elderly patients. [4] Calcium channel blockers are also frequently used to alter heart rate (especially from atrial fibrillation), to prevent peripheral and cerebral vasospasm , and to reduce chest pain caused by ...
Cardiovascular system damage can include myocardial ischemia/infarction, acute left ventricular dysfunction, acute pulmonary edema, and aortic dissection. Other end-organ damage can include acute kidney failure or insufficiency, retinopathy, eclampsia, lung cancer, brain cancer, leukemia and microangiopathic hemolytic anemia. [citation needed]
The use of racemic amlodipine is commonly associated with adverse events like peripheral edema and other side effects like headache, dizziness, flushing and abdominal pain. [13] Controlled clinical trials showed that levamlodipine is rarely associated with these side effects. [ 14 ]
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