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In organic synthesis, the complex diethylaniline·borane (DEANB) is used as a reducing agent. [4] Diethylaniline and dimethylaniline are both used as acid-absorbing bases. The advantage to the diethyl derivative is that [C 6 H 5 NEt 2 H]Cl is non-hygroscopic, in contrast to [C 6 H 5 NMe 2 H]Cl. [5]
N-Methylaniline (NMA) is an aniline derivative.It is an organic compound with the chemical formula C 6 H 5 NH(CH 3).The substance is a colorless viscous liquid, Samples turn brown when exposed to air.
Consisting of a phenyl group (−C 6 H 5) attached to an amino group (−NH 2), aniline is the simplest aromatic amine. It is an industrially significant commodity chemical, as well as a versatile starting material for fine chemical synthesis. Its main use is in the manufacture of precursors to polyurethane, dyes, and other industrial chemicals.
This reaction is also known as the Skraup-Doebner-Von Miller quinoline synthesis, and is named after the Czech chemist Zdenko Hans Skraup (1850–1910), and the Germans Oscar Döbner (Doebner) (1850–1907) and Wilhelm von Miller (1848–1899).
Another example is in the synthesis of antimalarials as aminoalkylamino derivatives of 2,3-dihydrofuroquinolines [9] These compounds are used as antimalarials. The Gould reaction is also used to convert 5-aminoindole to quinolines for the purpose of synthesizing pyrazolo[4,3- c ]pyrrolo[3,2- f ]quinolin-3-one derivatives as modified ...
In organic chemistry, the Mannich reaction is a three-component organic reaction that involves the amino alkylation of an acidic proton next to a carbonyl (C=O) functional group by formaldehyde (H−CHO) and a primary or secondary amine (−NH 2) or ammonia (NH 3). [1] The final product is a β-amino-carbonyl compound also known as a Mannich base.
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[1] [2] [3] The outcome of the reaction depends on reaction conditions. With water and a protic acid such as sulfuric acid as the reaction medium and formaldehyde the reaction product is a 1,3-diol (3). When water is absent, the cationic intermediate loses a proton to give an allylic alcohol (4).