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The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
Symptoms of Green Tobacco Sickness may begin while at work or hours after the conclusion of the workday. They do not typically persist for more than one day. [3] The primary symptoms of GTS can be separated into two categories, neurological and respiratory. Those referred to as neurological complaints include headaches, dizziness, nausea ...
The initial symptoms of nicotine poisoning may include rapid heart rate, sweating, feeling sick, and throwing up, and delayed symptoms include low blood pressure, seizures, and hypoventilation. [120] Rare serious effects included coma, seizure, trouble breathing, and heart attack. [121]
The onset of these symptoms is very fast, nicotine's half-life being only two hours. [153] The psychological dependence may linger for months or even many years. Unlike some recreational drugs, nicotine does not measurably alter a smoker's motor skills, judgement, or language abilities while under the influence of the drug. Nicotine withdrawal ...
These symptoms can include cravings for nicotine, anger, irritability, anxiety, depression, impatience, trouble sleeping, restlessness, hunger, weight gain, and difficulty concentrating. [61] When trying to quit smoking with vaping a base containing nicotine, symptoms of withdrawal can include irritability, restlessness, poor concentration ...
Nicotine has been shown to produce birth defects in humans and is considered a teratogen. [42] [43] The median lethal dose of nicotine in humans is unknown. [44] High doses are known to cause nicotine poisoning, organ failure, and death through paralysis of respiratory muscles, [41] [45] though serious or fatal overdoses are rare. [46]
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Nicotine withdrawal is a group of symptoms that occur in the first few weeks after stopping or decreasing use of nicotine. Symptoms include intense cravings for nicotine, anger or irritability , anxiety , depression , impatience, trouble sleeping , restlessness , hunger , weight gain , and difficulty concentrating.