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Aripiprazole was frequently found to be a partial agonist or full agonist, with an intrinsic activity that could be low (5-HT 2A, 5-HT 7), intermediate (D 2L, 5-HT1A), or high (5-HT 2C). This mixture of agonist actions at D2-dopamine receptors is consistent with the hypothesis that aripiprazole has "functionally selective" actions. [92]
A dopamine agonist is a compound that activates dopamine receptors. ... (Partial agonist of the D 2 family receptors - Trade name "Abilify" in the United States; ...
Aripiprazole (Abilify) – dopamine D 2 and D 3 partial agonist, serotonin 5-HT 1A and 5-HT 7 receptor partial agonist, serotonin 5-HT 2A and 5-HT 2B receptor antagonist or inverse agonist, and atypical antipsychotic [96] [97]
AR-08 – adrenergic receptor agonist [65] Aripiprazole (Abilify, Abilify Maintena, Abilify MyCite, Abilitat, Ao Pai, Aripiprazole depot, Aripiprazole ECER tablets, Arlemide; OPC-14597, OPC-14597 IMD, OPC-31) – atypical antipsychotic / dopamine receptor partial agonist and serotonin receptor modulator [66]
Aripiprazole lauroxil (Abilify Maintena) – Long-acting version of aripiprazole for injection. Brexpiprazole (Rexulti) – Partial agonist of the D 2 receptor. Successor of aripiprazole. Brilaroxazine – A D 2/3/4 and 5-HT 1A partial agonist and 5-HT 2A/2B/7 antagonist; Cariprazine (Vraylar, Reagila) – A D 3-preferring D 2/3 partial agonist.
Dopamine receptor D 2, also known as D 2 R, is a protein that, in humans, is encoded by the DRD2 gene.After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D 2 receptor. [5]
“Dopamine allows neurons to communicate with each other,” says Anthony Rostain, M.D., chair of the department of psychiatry and behavior health at Cooper University Health Care. “It helps ...
Abilify (aripiprazole) – atypical antipsychotic used to treat schizophrenia, bipolar disorder, and irritability associated with autism; Adderall (mixed amphetamine salts) – a stimulant used to treat ADHD; Ambien – nonbenzodiazepine used as a sleep aid; Anafranil (clomipramine) – a tricyclic antidepressant; mostly used to treat OCD
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