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NETA, also known as norethinyltestosterone acetate, as well as 17α-ethynyl-19-nortestosterone 17β-acetate or 17α-ethynylestra-4-en-17β-ol-3-one 17β-acetate, is a progestin, or synthetic progestogen, of the 19-nortestosterone group, and a synthetic estrane steroid. [2] [5] It is the C17β acetate ester of norethisterone.
[49] [50] A study of 194 women treated with 5 to 15 mg/day norethisterone acetate for a median duration of 13 months of therapy to suppress symptoms of endometriosis observed no side effects in 55.2% of patients, weight gain in 16.1%, acne in 9.9%, mood lability in 8.9%, hot flashes in 8.3%, and voice deepening in two women (1.0%). [52]
The drug label for the combination includes a boxed warning about the risk of vascular events (strokes) and thrombotic or thromboembolic disorders (blood clots), especially in women at increased risk for these events.
Experts point to the medical positives associated with the drugs beyond weight loss. However, other experts remain cautious. Weight loss on these drugs seems to come from eating very little as the ...
Powerful weight-loss drugs are expanding use of U.S. health care as patients starting prescriptions are diagnosed with obesity-related conditions or take the drugs to become eligible for other ...
Ozempic and Wegovy, medications taken for both weight loss and Type 2 diabetes, have become household names, but an increasing number of people are reporting a range of complications.
The most common side effects of the medication include hot flushes, excessive sweating or night sweats, uterine bleeding, hair loss or thinning, and decreased interest in sex. [8] The medication was approved for medical use in the United States in May 2021, [8] [11] [12] and in the European Union in July 2021. [9]
Many drugs have very specific mechanisms of action, and their side effects can be more easily anticipated, but GLP-1s (like Ozempic, Wegovy and Mounjaro) that mimic the actions of a hormone are ...