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A diagnosis of vitamin B 12 deficiency is determined by blood levels lower than 200 or 250 picograms per ml (148 or 185 picomoles per liter). [3] Some people can have symptoms with their normal levels of the vitamin, or may have low levels despite having no symptoms. [5] Other tests may be done to ensure individuals status. [3]
Diagnosis is not always straightforward as serum levels can be falsely high or normal. [10] Elevated methylmalonic acid levels may also indicate a deficiency. [2] Individuals with low or marginal values of vitamin B 12 in the range of 148–221 pmol/L (200–300 pg/mL) may not have classic neurological or hematological signs or symptoms. [2]
Lack of vitamin B12 can cause megaloblastic anemia—a condition characterized by larger than normal red blood cells in a smaller than normal amount. This causes fatigue, paleness in the skin ...
A vitamin B12 level of less than 200 pg/mL is considered deficient. Treatment First, have your health care provider run blood tests to see if you truly have a B12 deficiency.
Reduced serum levels of vitamin B 12 occur in up to 30% of people taking long-term anti-diabetic metformin. [105] [106] Deficiency does not develop if dietary intake of vitamin B 12 is adequate or prophylactic B 12 supplementation is given. If the deficiency is detected, metformin can be continued while the deficiency is corrected with B 12 ...
Most adults need 2.4 micrograms of vitamin B12 a day, although the numbers are slightly higher during pregnancy and breastfeeding. Causes of vitamin B12 deficiency There are a few reasons why ...
Normal serum levels may be found in cases of deficiency where myeloproliferative disorders, liver disease, transcobalamin II, or small intestinal bacterial overgrowth are present. [ 56 ] [ 57 ] Low levels of serum vitamin B 12 may be caused by other factors than B 12 deficiency, such as folate deficiency , pregnancy , oral contraceptive use ...
Feeling low-energy? You could be among the estimated 3.6% of Americans who are deficient and 12.5% who get insufficient amounts of vitamin B12.. The first step to finding out is seeing your doctor ...
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