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In genetics, the coefficient of coincidence (c.o.c.) is a measure of interference in the formation of chromosomal crossovers during meiosis. It is generally the case that, if there is a crossover at one spot on a chromosome, this decreases the likelihood of a crossover in a nearby spot. [1] This is called interference.
Crossover interference is the term used to refer to the non-random placement of crossovers with respect to each other during meiosis.The term is attributed to Hermann Joseph Muller, who observed that one crossover "interferes with the coincident occurrence of another crossing over in the same pair of chromosomes, and I have accordingly termed this phenomenon ‘interference’."
Crossover in evolutionary algorithms and evolutionary computation, also called recombination, is a genetic operator used to combine the genetic information of two parents to generate new offspring. It is one way to stochastically generate new solutions from an existing population, and is analogous to the crossover that happens during sexual ...
Where d is the distance in map units, the Morgan Mapping Function states that the recombination frequency r can be expressed as =.This assumes that one crossover occurs, at most, in an interval between two loci, and that the probability of the occurrence of this crossover is proportional to the map length of the interval.
In genetics, a centimorgan (abbreviated cM) or map unit (m.u.) is a unit for measuring genetic linkage. It is defined as the distance between chromosome positions (also termed loci or markers) for which the expected average number of intervening chromosomal crossovers in a single generation is 0.01. It is often used to infer distance along a ...
In genetics, a three-point cross is used to determine the loci of three genes in an organism's genome.. An individual heterozygous for three mutations is crossed with a homozygous recessive individual, and the phenotypes of the progeny are scored.
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In population genetics, the Hill–Robertson effect, or Hill–Robertson interference, is a phenomenon first identified by Bill Hill and Alan Robertson in 1966. [1] It provides an explanation as to why there may be an evolutionary advantage to genetic recombination .