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One of the most widely practiced treatments for speech disorders associated with Parkinson's disease is the Lee Silverman voice treatment (LSVT). [25] [29] Speech therapy and specifically LSVT may improve speech. [25] People with Parkinson's disease can develop dysarthria which is characterized by reduced speech intelligibility.
DRT has been used to improve motor skills, impulsivity, and decision making in Parkinson's patients. [1] In Parkinson's disease patients, dopamine deficiencies can be seen in two key areas of the brain: the dorsal frontostriatal circuit, the area responsible for motor skills and task-switching, and the ventral frontostriatal circuit, the area responsible for impulsivity. [1]
However, with this treatment, the number of substantia nigra neurons decrease so it becomes less efficient. [2] These treatments try to reduce the symptoms of the patient focusing on increasing the production of dopamine but they do not cure the disease. The new treatments for PD are in clinical trials and most of them are centered on gene therapy.
On Thursday, the FDA approved AbbVie Inc’s (NYSE:ABBV) Vyalev (foscarbidopa and foslevodopa) as the first and only subcutaneous 24-hour infusion of levodopa-based therapy for motor fluctuations ...
Trade names include Sinemet, Pharmacopa, Atamet, and Stalevo. As a drug, it is used in the clinical treatment of Parkinson's disease and dopamine-responsive dystonia. l-DOPA has a counterpart with opposite chirality, d-DOPA. As is true for many molecules, the human body produces only one of these isomers (the l-DOPA form).
Levodopa-induced dyskinesia (LID) is a form of dyskinesia associated with levodopa (l-DOPA), used to treat Parkinson's disease. It often involves hyperkinetic movements, including chorea, dystonia, and athetosis. [1] In the context of Parkinson's disease (PD), dyskinesia is often the result of long-term dopamine therapy.
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