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Direct halogenation of pyridine with chlorine gas above 270 °C gives a mixture of 2-chloropyridine and 2,6-dichloropyridine. [1] 2- and 4-chloropyridine are prepared from the corresponding pyridinols using phosphoryl chloride. [1]
2-Chloropyridine is an aryl chloride with the formula C 5 H 4 ClN. It is a colorless liquid that is mainly used to generate fungicides and insecticides in industry. It also serves to generate antihistamines and antiarrythymics for pharmaceutical purposes. [2] It is one of three isomers of chloropyridine.
2-Bromopyridine reacts with butyllithium to give 2-lithiopyridine, [2] which is a versatile reagent. [3] Pyrithione can be prepared in a two-step synthesis from 2-bromopyridine by oxidation to the N-oxide with a suitable peracid followed by substitution using either sodium dithionite or sodium sulfide with sodium hydroxide to introduce the thiol functional group.
substitution in the 2-position substitution in the 3-position Substitution in 4-position. Direct nitration of pyridine is sluggish. [89] [90] Pyridine derivatives wherein the nitrogen atom is screened sterically and/or electronically can be obtained by nitration with nitronium tetrafluoroborate (NO 2 BF 4). In this way, 3-nitropyridine can be ...
C 4 H 7 NO 3: aceturic acid: C 4 H 7 NO 4: aspartic acid Asp: 56-84-8 C 4 H 8: cyclobutane: 287-23-0 C 4 H 8 N 2 O 3: asparagine Asn: 70-47-3 C 4 H 8 O: tetrahydrofuran THF: 109-99-9 C 4 H 8 O 2: ethyl acetate: C 4 H 8 O 3: gamma-Hydroxybutyric acid: 591-81-1 C 4 H 9 ClHg n-Butylmercuric chloride: 543-63-5 C 4 H 9 Li: n-butyllithium: C 4 H 9 NO ...
It is one of three isomeric chloromethylpyridines, along with 3- and 4-chloromethylpyridine. It is an alkylating agent . 2-Chloromethylpyridine is a precursor to pyridine-containing ligands . [ 1 ] [ 2 ]
Pyridine-N-oxide is the heterocyclic compound with the formula C 5 H 5 NO. This colourless, hygroscopic solid is the product of the oxidation of pyridine. It was originally prepared using peroxyacids as the oxidising agent. The compound is used infrequently as an oxidizing reagent in organic synthesis. [1]
The reaction of 3-bromo-4-chloropyridine with furan and lithium amalgam gives 1,4-epoxy-dihydroquinoline through the 2,3-pyridyne intermediate. The reaction of 4-bromopyridine with sodium in liquid ammonia gives both 3-aminopyridine and 4-aminopyridine through the 3,4-pyridyne intermediate and an E1cB-elimination reaction. [2]