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Cori cycle. The Cori cycle (also known as the lactic acid cycle), named after its discoverers, Carl Ferdinand Cori and Gerty Cori, [1] is a metabolic pathway in which lactate, produced by anaerobic glycolysis in muscles, is transported to the liver and converted to glucose, which then returns to the muscles and is cyclically metabolized back to lactate.
In 1941, she moved to the Washington University in St. Louis in Missouri, where she worked with Gerty Cori and Carl Cori as an assistant professor of biochemistry. [10] Green isolated pure phosphorylase , a key enzyme in the Cori cycle pathway that breaks down the sugar storage molecule glycogen , playing a critical role in the elucidation of ...
[1] Anaerobic glycolysis is thought to have been the primary means of energy production in earlier organisms before oxygen was at high concentration in the atmosphere and thus would represent a more ancient form of energy production in cells. In mammals, lactate can be transformed by the liver back into glucose using the Cori cycle.
Carl Ferdinand Cori, ForMemRS [1] (December 5, 1896 – October 20, 1984) was a Czech-American biochemist and pharmacologist. He, together with his wife Gerty Cori and Argentine physiologist Bernardo Houssay , received a Nobel Prize in 1947 for their discovery of how the glucose derivative glycogen (animal starch) is broken down and ...
It is also known as Cori's disease in honor of the 1947 Nobel laureates Carl Cori and Gerty Cori. Other names include Forbes disease in honor of clinician Gilbert Burnett Forbes (1915–2003), an American physician who further described the features of the disorder, or limit dextrinosis , due to the limit dextrin-like structures in cytosol . [ 2 ]
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The Cori cycle (lactic acid cycle) Gerty Cori, together with Carl Ferdinand Cori, discovered the Cori cycle, the metabolic pathway in which lactate produced by anaerobic glycolysis in the muscles moves to the liver and is converted to glucose, which then returns to the muscles and is metabolized back to lactate. [83] Radioimmunoassay