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Why do antidepressants contribute to weight gain? Science doesn’t yet know, Perlis said. “Remarkably, we don’t know the precise mechanism by which antidepressants contribute to weight changes.
One theory to explain antidepressant-related weight gain is that psychotropic medications such as antidepressants can affect neurotransmitters involved in eating behavior, causing an increase in ...
Monoamine reuptake inhibitors, including DRIs, have proven quite effective in managing excessive food consumption and regulating appetite in obese patients. Though such pharmacotherapy is still available, the majority of stimulant anorectics marketed for this purpose have been withdrawn or discontinued due to adverse side effects such as ...
However, most antidepressant treatments do not directly enhance DA neurotransmission, which may contribute to residual symptoms, including impaired motivation, concentration, and pleasure. [ 21 ] Preclinical and clinical research indicates that drugs inhibiting the reuptake of all three of these neurotransmitters can produce a more rapid onset ...
This side effect has been particularly associated with serotonergic antidepressants like SSRIs and SNRIs, but may be less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. [ 83 ] [ 85 ] [ 86 ] Higher doses of antidepressants seem to be more likely to produce emotional blunting than lower doses. [ 83 ]
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This translates to the 2nd- and 3rd-most-common antidepressants, behind Lexapro (escitalopram), an SSRI. [87] In some studies, SNRIs demonstrated slightly higher antidepressant efficacy than the SSRIs (response rates 63.6% versus 59.3%). [43] However, in one study escitalopram had a superior efficacy profile to venlafaxine. [88]
Popular Over-the-Counter Antidepressant Alternatives. So yes, there are big differences between antidepressants and over-the-counter meds. However, some people definitely think they benefit from ...