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The protein has several domains of which domain D1 contains the polio virus binding site. Within this domain, 37 amino acids are responsible for binding the virus. Poliovirus is an enterovirus. Infection occurs via the fecal–oral route, meaning that one ingests the virus and viral replication occurs in the gastrointestinal tract. [42]
CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. [8]Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy [9] while a high resolution structures of the ectodomain D1 and D2 of CD155 were solved by x-ray crystallography.
Poliomyelitis (/ ˌ p oʊ l i oʊ ˌ m aɪ ə ˈ l aɪ t ɪ s / POH-lee-oh-MY-ə-LY-tiss), commonly shortened to polio, is an infectious disease caused by the poliovirus. [1] Approximately 75% of cases are asymptomatic; [5] mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia.
The virus infects the throat and intestines, and can cause flu-like symptoms. Paralysis from the polio virus is rare. This year, polio cases have been detected in New York state, London and Jerusalem.
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Polio is “shorthand for poliomyelitis, a disease of the central nervous system caused by infection with poliovirus,” Dr. Richard Lloyd, professor of molecular virology and microbiology at ...
For roughly 80 years, she has coped with the aftermath of a polio infection, including the late effects of polio, called post-polio syndrome. She now needs a wheelchair or mobility scooter to get ...
Wimmer's major early accomplishment, spearheaded by Naomi Kitamura and other members of his laboratory, was the elucidation in 1981 of the structure and genetic organization of the poliovirus genome, [4] the first sequence of a eukaryotic RNA virus. The primary structure of the genome was unique at the time amongst RNA viruses as it was 3 ...