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[5] [6] Worldwide, the prevalence of cSLE is 1.9–25.7 per 100,000 children and its incidence is 0.3–0.9 per 100,000 per year. [7] While there are similarities between the childhood and adult forms of SLE (i.e., aSLE), cSLE has several characteristics that make it a clinical entity distinct from aSLE.
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[7] [8] [6] It differs from the similarly named prednisone in having a hydroxyl at the 11th carbon instead of a ketone. Common side effects with short-term use include nausea, difficulty concentrating, insomnia, increased appetite, and fatigue. [5] More severe side effects include psychiatric problems, which may occur in about 5% of people. [9]
Prednisone is a prodrug and must be converted to prednisolone by the liver before it becomes active. [6] [7] Prednisolone then binds to glucocorticoid receptors, activating them and triggering changes in gene expression. [4] Prednisone was patented in 1954 and approved for medical use in the United States in 1955.
A variety of steroid medications, from anti-allergy nasal sprays (Nasonex, Flonase) to topical skin creams, to eye drops , to prednisone have been implicated in the development of central serous retinopathy (CSR). [6] [7] Corticosteroids have been widely used in treating people with traumatic brain injury. [8]
once a day (United Kingdom) oculus dexter omne in die o.s., os, OS ... take by mouth 3 times a day ter die sumendus u.d., ud as directed: ut dictum References
Treatment is usually started by administering drugs with high anti-inflammatory effects, such as prednisone. Once the inflammation is successfully controlled, another drug to keep the disease in remission, such as mesalazine in UC, is the main treatment. If further treatment is required, a combination of an immunosuppressive drug (such as ...
At age 45, women should be able to do 14 pushups, while men should aim for 16. ... At 45, the time increases to 14 minutes for women, and 12 for me. By the time you hit 65, women should be able to ...
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