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So, the maintenance dose of foosporin is 100 milligrams (100 mg) per day—just enough to offset the amount cleared. Suppose a patient just started taking 100 mg of foosporin every day. On the first day, they'd have 100 mg in their system; their body would clear 10 mg, leaving 90 mg.
The use of trapezoidal rule in AUC calculation was known in literature by no later than 1975, in J.G. Wagner's Fundamentals of Clinical Pharmacokinetics. A 1977 article compares the "classical" trapezoidal method to a number of methods that take into account the typical shape of the concentration plot, caused by first-order kinetics. [8]
An example for a simple case (mono-compartmental) would be to administer D=8 mg/kg to a human. A human has a blood volume of around V b l o o d = {\displaystyle V_{blood}=} 0.08 L/kg . [ 7 ] This gives a C 0 = {\displaystyle C_{0}=} 100 μg/mL if the drug stays in the blood stream only, and thus its volume of distribution is the same as V b l o ...
The concept of Ct was first proposed by Fritz Haber and is sometimes referred to as Haber's law, which assumes that exposure to 1 minute of 100 mg/m 3 is equivalent to 10 minutes of 10 mg/m 3 (1 × 100 = 100, as does 10 × 10 = 100). [citation needed]
Near the surface of the Earth, the acceleration due to gravity g = 9.807 m/s 2 (metres per second squared, which might be thought of as "metres per second, per second"; or 32.18 ft/s 2 as "feet per second per second") approximately. A coherent set of units for g, d, t and v is essential.
“Public transportation and taxis are generally quite reasonable in this city and entrance to museums won’t set you back more than about $20 to $50 per day,” she said.
Latisha Doty, 46, and Alison Bocking, 48, have each lost more than 100 lbs.—and gained a lifelong friend in the process
The SI unit of measure for equivalent dose is the sievert, defined as one Joule per kg. [11] In the United States the roentgen equivalent man (rem), equal to 0.01 sievert, is still in common use, although regulatory and advisory bodies are encouraging transition to sievert.