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  2. Protein - Wikipedia

    en.wikipedia.org/wiki/Protein

    With the development of X-ray crystallography, it became possible to determine protein structures as well as their sequences. [25] The first protein structures to be solved were hemoglobin by Max Perutz and myoglobin by John Kendrew, in 1958. [26] [27] The use of computers and increasing computing power also supported the sequencing of complex ...

  3. Protein structure - Wikipedia

    en.wikipedia.org/wiki/Protein_structure

    The generation of a protein sequence is much easier than the determination of a protein structure. However, the structure of a protein gives much more insight in the function of the protein than its sequence. Therefore, a number of methods for the computational prediction of protein structure from its sequence have been developed. [39]

  4. Anfinsen's dogma - Wikipedia

    en.wikipedia.org/wiki/Anfinsen's_dogma

    Folded, 3-D structure of ribonuclease A. Anfinsen's dogma, also known as the thermodynamic hypothesis, is a postulate in molecular biology.It states that, at least for a small globular protein in its standard physiological environment, the native structure is determined only by the protein's amino acid sequence. [1]

  5. Structural genomics - Wikipedia

    en.wikipedia.org/wiki/Structural_genomics

    An example of a protein structure from Protein Data Bank.. Structural genomics seeks to describe the 3-dimensional structure of every protein encoded by a given genome.This genome-based approach allows for a high-throughput method of structure determination by a combination of experimental and modeling approaches.

  6. Central dogma of molecular biology - Wikipedia

    en.wikipedia.org/wiki/Central_dogma_of_molecular...

    Some proteins are synthesized by nonribosomal peptide synthetases, which can be big protein complexes, each specializing in synthesizing only one type of peptide. Nonribosomal peptides often have cyclic and/or branched structures and can contain non-proteinogenic amino acids - both of these factors differentiate them from ribosome synthesized ...

  7. Molecular biophysics - Wikipedia

    en.wikipedia.org/wiki/Molecular_biophysics

    As the three-dimensional structure of proteins brings with it an understanding of its function and biological context, there is great effort placed in observing the structures of proteins. X-ray crystallography was the primary method used in the 20th century to solve the structures of proteins in their crystalline form.

  8. Protein primary structure - Wikipedia

    en.wikipedia.org/wiki/Protein_primary_structure

    Protein primary structure is the linear sequence of amino acids in a peptide or protein. [1] By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end. Protein biosynthesis is most commonly performed by ribosomes in cells. Peptides can also be synthesized in the ...

  9. Structural biology - Wikipedia

    en.wikipedia.org/wiki/Structural_biology

    Pepsin crystals were the first proteins to be crystallized for use in X-ray diffraction, by Theodore Svedberg who received the 1962 Nobel Prize in Chemistry. [9] The first tertiary protein structure, that of myoglobin, was published in 1958 by John Kendrew. [10] During this time, modeling of protein structures was done using balsa wood or wire ...