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In genetics, the coefficient of coincidence (c.o.c.) is a measure of interference in the formation of chromosomal crossovers during meiosis. It is generally the case that, if there is a crossover at one spot on a chromosome, this decreases the likelihood of a crossover in a nearby spot. [1] This is called interference.
The Kosambi mapping function was introduced to account for the impact played by crossover interference on recombination frequency. It introduces a parameter C, representing the coefficient of coincidence, and sets it equal to 2r. For loci which are strongly linked, interference is strong; otherwise, interference decreases towards zero. [5]
Crossover interference is the term used to refer to the non-random placement of crossovers with respect to each other during meiosis.The term is attributed to Hermann Joseph Muller, who observed that one crossover "interferes with the coincident occurrence of another crossing over in the same pair of chromosomes, and I have accordingly termed this phenomenon ‘interference’."
Most of these events involve an exchange of equal amounts of genetic information, but unequal exchanges may occur due to sequence mismatch. These are referred to by a variety of names, including non-homologous crossover, unequal crossover, and unbalanced recombination, and result in an insertion or deletion of genetic information into the ...
Journal of Bioinformatics and Computational Biology; Journal of Biomedical Informatics; Journal of Computational Biology; Journal of Mathematical Biology; Journal of Theoretical Biology; PLOS Computational Biology; Source Code for Biology and Medicine; Statistical Applications in Genetics and Molecular Biology; Statistics in Biosciences
Luck. Fate. Blessing. A glitch in the matrix. Or, if you’re more skeptical, just a coincidence.. It’s a phenomenon that, from a statistical perspective, is random and meaningless.
The Annals of Human Genetics is a bimonthly peer-reviewed scientific journal covering human genetics. It was established in 1925 by Karl Pearson as the Annals of Eugenics , with as subtitle, Darwin's epigram "I have no Faith in anything short of actual measurement and the rule of three ". [ 1 ]
Epps, 51, also faced an internal affairs investigation into her overtime, sources said. Records showed that last year she worked nearly 1,627 hours of overtime on top of her regular shift, or an ...