Search results
Results from the WOW.Com Content Network
Cotinine has an in vivo half-life of approximately 20 hours, and is typically detectable for several days (up to one week) after the use of tobacco. The level of cotinine in the blood, saliva, and urine is proportionate to the amount of exposure to tobacco smoke, so it is a valuable indicator of tobacco smoke exposure, including secondary (passive) smoke. [14]
So, for example, digoxin has a half-life (or t 1 / 2 ) of 24–36 h; this means that a change in the dose will take the best part of a week to take full effect. For this reason, drugs with a long half-life (e.g., amiodarone, elimination t 1 / 2 of about 58 days) are usually started with a loading dose to achieve their desired ...
A drug's characteristics make a clear distinction between tissues with high and low blood flow. Enzymatic saturation: When the dose of a drug whose elimination depends on biotransformation is increased above a certain threshold the enzymes responsible for its metabolism become saturated. The drug's plasma concentration will then increase ...
[22] [23] However, urine drug screens that test for a specific drug, rather than an entire class, are often available. When an employer requests a drug test from an employee, or a physician requests a drug test from a patient, the employee or patient is typically instructed to go to a collection site or their home.
Methcathinone / ˌ m ɛ θ ˈ k æ θ ɪ ˌ n oʊ n / (α-methyl amino-propiophenone or ephedrone) (sometimes called "cat" or "jeff" or "catnip" or "M-Kat" or "kat" or "intash") is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone.
Illustration showing the hepatic portal vein system. The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation.
AOL Mail is free and helps keep you safe. From security to personalization, AOL Mail helps manage your digital life Start for free
He named the drug after his wife Marguerite, nicknamed Rita, who used Ritalin to compensate for low blood pressure. [154] [155] Methylphenidate was not reported to be a stimulant until 1954. [156] [157] The drug was introduced for medical use in the United States in 1957. [158]