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A brain metastasis is a cancer that has metastasized (spread) to the brain from another location in the body and is therefore considered a secondary brain tumor. [ 1 ] [ 2 ] The metastasis typically shares a cancer cell type with the original site of the cancer. [ 3 ]
Tucatinib is a kinase inhibitor indicated in combination with trastuzumab and capecitabine for the treatment of adults with advanced unresectable or metastatic HER2-positive breast cancer, including those with brain metastases, who have received one or more prior anti-HER2-based regimens in the metastatic setting. [3]
Effective treatments for brain metastases from breast cancer exist, although symptomatic therapy alone may be chosen for those with poor performance status. Corticosteroids are crucial to the treatment of brain metastases from any source (including the breast), and are effective in reducing peri-tumoral edema and providing symptomatic relief.
Stage 3 breast cancer is often considered treatable, with 86% of patients surviving five or more years, the American Cancer Society says. However, Stage 4 breast cancer, also known as metastatic ...
Brain CT scan showing CNS metastasis from the breast, the primary source. CNS metastasis is the spread and proliferation of cancer cells from their original tumour to form secondary tumours in portions of the central nervous system .
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
In 2015, a person with metastatic melanoma — a form of skin cancer that has spread throughout the body — was unlikely to survive more than six months, and possibly not even six weeks if he or ...
ALK-positive cancer occurs in humans mostly as lung cancer, but it can also originate in many other parts of the body, including brain and breast. ALK-positive lung cancer occurs in approximately ...
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