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The medical problems that are direct consequence of high altitude are caused by the low inspired partial pressure of oxygen, which is caused by the reduced atmospheric pressure, and the constant gas fraction of oxygen in atmospheric air over the range in which humans can survive. [1]
Dehydration due to the higher rate of water vapor lost from the lungs at higher altitudes may contribute to the symptoms of altitude sickness. [13] The rate of ascent, altitude attained, amount of physical activity at high altitude, as well as individual susceptibility, are contributing factors to the onset and severity of high-altitude illness.
Re-entry HAPE is also an entity that has been described in persons who normally live at high altitude but who develop pulmonary edema after returning from a stay at low altitude. [3] If HAPE is not treated, there is a 50% risk of mortality. [4] Symptoms include crackling sounds when breathing, dyspnea (at rest), and cyanosis. [4]
Hyperpnea is distinguished from tachypnea, which is a respiratory rate greater than normal, resulting in rapid and shallow breaths, but not necessarily increasing volume in breathing. [1] Hyperpnea is also distinguished from hyperventilation , which is over-ventilation (an increase in minute ventilation ), which involves an increase in volume ...
Respiratory failure is classified as either Type 1 or Type 2, based on whether there is a high carbon dioxide level, and can be acute or chronic. In clinical trials, the definition of respiratory failure usually includes increased respiratory rate , abnormal blood gases (hypoxemia, hypercapnia, or both), and evidence of increased work of breathing.
CMS was first described in 1925 by Carlos Monge Medrano, a Peruvian doctor who specialised in diseases of high altitude. [3] While acute mountain sickness is experienced shortly after ascent to high altitude, chronic mountain sickness may develop only after many years of living at high altitude. In medicine, high altitude is defined as over ...
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In those with underlying heart or lung disease, effective control of congestive and respiratory symptoms can help prevent pulmonary edema. [37] Dexamethasone is in widespread use for the prevention of high altitude pulmonary edema. Sildenafil is used as a preventive treatment for altitude-induced pulmonary edema and pulmonary hypertension.