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Intravitreal injection is the method of administration of drugs into the eye by injection with a fine needle. The medication will be directly applied into the vitreous humor . [ 1 ] It is used to treat various eye diseases, such as age-related macular degeneration (AMD) , diabetic retinopathy , and infections inside the eye such as ...
"Intravitreal" literally means "inside an eye". Intravitreal injections were first introduced in 1911 when Ohm gave an injection of air into the vitreous humor to repair a detached retina. In the mid-1940s, intravitreal injections became a standard way to administer drugs to treat endophthalmitis and cytomegalovirus retinitis. [1]
Intravitreal injections are already commonly used for administering drugs like anti-VEGF agents, making the procedure familiar to clinicians and safer for patients. The eye's immune-privileged status reduces the likelihood of immune responses to the viral vector, increasing the therapy's safety profile.
An intracameral injection is usually of an antibiotic into the anterior chamber of the eyeball to prevent endophthalmitis caused by an infection of the eye that can occur after cataract surgery. The Food and Drug Administration (FDA) has not approved antibiotics for this use and it is considered 'off-label'.
Intravitreal injections are a rare cause, with an incidence rate usually less than 0.05%. Endophthalmitis requires immediate medical attention to ensure the condition is diagnosed as soon as possible and treatment is started in order to reduce the risk of the person losing vision in the eye. [2]
How can you tell if they’re safe past their expiration dates? Here, doctors explain how long most vitamins last and any risks associated with taking expired vitamins.
For children who have GHD, synthetic HGH supports organ development and can help get kids back on a reasonable trajectory of linear growth, says Eisenberg. Taking growth hormone has the potential ...
Also intravitreal injections, an injection of medicine into the vitreous near the retina, of foscarnet in concomitance with oral valganciclovir can be used for treatment as well. [ 15 ] [ 2 ] [ 16 ] Often individuals with CMV retinitis will need surgery for either retinal detachment or intravitreal instillation of ganciclovir.