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[8] [9] Gallstones are more common among women than men and occur more commonly after the age of 40. [2] Gallstones occur more frequently among certain ethnic groups than others. [2] For example, 48% of Native Americans experience gallstones, whereas gallstone rates in many parts of Africa are as low as 3%.
Gallstones may result from increased saturation of cholesterol or bilirubin, or from bile stasis. Lower concentrations of bile acids or phospholipids in bile reduce cholesterol solubility and lead to microcrystal formation. Oral therapy with chenodeoxycholic acid and/or ursodeoxycholic acid has been used to dissolve cholesterol gallstones.
CDCA has been used as medical therapy to dissolve gallstones. [ 7 ] [ 8 ] Medical therapy with oral bile acids has been used in patients who have small cholesterol stones, and for patients with larger cholesterol gallstones who are unable or reluctant to have surgery.
How long do symptoms last? They peak at 24 to 48 hours but can last up to 72 hours, says Dr. Dibba. Norovirus tends to hit hard and then fade fairly quickly. Symptoms do ramp up in intensity, however.
There are articles on the web (mainly medical research documents) that talk about using methyl tert-butyl ether (MTBE) or ethyl propionate to dissolve gallstones. In those articles, the rate of dissolved stones ranges from ~60% to ~95%. Does anyone knows about more recent studies that had results published?
U.S. Surgeon General Dr. Vivek Murthy warned in a recent advisory about alcohol use increasing cancer risk. The advisory notes that alcohol can increase the risk of throat, liver, esophageal ...
Cholic acid downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis), and cholesterol does the opposite. This is why chenodeoxycholic acid, and not cholic acid, can be used to treat gallstones (because decreasing bile acid synthesis would supersaturate the stones even more).
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