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Further downstream, phosphate signal activates MAPK (also known as ERK). Bottom, signal enters the cell nucleus and causes transcription of DNA, which is then expressed as protein. The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the ...
Mitogen-activated protein kinase (MAPK) networks are the pathways and signaling of MAPK, which is a protein kinase that consists of amino acids serine and threonine. [1] MAPK pathways have both a positive and negative regulation in plants. A positive regulation of MAPK networks is to help in assisting with stresses from the environment.
The first mitogen-activated protein kinase to be discovered was ERK1 in mammals. Since ERK1 and its close relative ERK2 are both involved in growth factor signaling, the family was termed "mitogen-activated". With the discovery of other members, even from distant organisms (e.g. plants), it has become increasingly clear that the name is a ...
Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) ... (MEK1 and MEK2) define independent MAP kinase signal transduction pathways. [1]
The signal transduction component labeled as "MAPK" in the pathway was originally called "ERK," so the pathway is called the MAPK/ERK pathway. The MAPK protein is an enzyme, a protein kinase that can attach phosphate to target proteins such as the transcription factor MYC and, thus, alter gene transcription and, ultimately, cell cycle progression.
Hippo signalling pathway; Insulin signal transduction pathway; JAK-STAT signalling pathway; MAPK/ERK signalling pathway; mTOR signalling pathway;
26401 Ensembl ENSG00000095015 ENSMUSG00000021754 UniProt Q13233 P53349 RefSeq (mRNA) NM_005921 NM_011945 RefSeq (protein) NP_005912 n/a Location (UCSC) Chr 5: 56.82 – 56.9 Mb Chr 13: 111.88 – 111.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is a signal transduction enzyme that in humans is encoded by the autosomal ...
MAP2K1 is also known as MEK1 (see Mitogen-activated protein kinase kinase). MEK1 is a meiotic chromosome-axis-associated kinase that is thought to slow down, but not entirely block, sister chromatid recombination. Loss of MEK1 allows inter-sister DSB repair and also inter-sister Holliday junction intermediates to increase.