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The congenital form of methemoglobinemia has an autosomal recessive pattern of inheritance. Due to a deficiency of the enzyme diaphorase I (cytochrome b5 reductase), methemoglobin levels rise and the blood of met-Hb patients has reduced oxygen-carrying capacity. Instead of being red in color, the arterial blood of met-Hb patients is brown.
A blood gas test or blood gas analysis tests blood to measure blood gas tension values, it also measures blood pH, and the level and base excess of bicarbonate.The source of the blood is reflected in the name of each test; arterial blood gases come from arteries, venous blood gases come from veins and capillary blood gases come from capillaries. [1]
Once the sample is obtained, [7] care is taken to eliminate visible gas bubbles, as these bubbles can dissolve into the sample and cause inaccurate results. The sealed syringe is taken to a blood gas analyzer. [8] If a plastic blood gas syringe is used, the sample should be transported and kept at room temperature and analyzed within 30 min.
For example, a methemoglobin concentration of 1.5 g/dL may represent a percentage of 10% in an otherwise healthy patient with a baseline hemoglobin of 15 mg/dL, whereas the presence of the same concentration of 1.5 g/dL of methemoglobin in an anemic patient with a baseline hemoglobin of 8 g/dL would represent a percentage of 18.75%.
This requires an arterial blood gas determination, which involves taking a blood sample from an artery, usually the radial artery. Given that it would be complicated to perform this test on every patient with sleep-related breathing problems, some suggest that measuring bicarbonate levels in normal (venous) blood would be a reasonable screening ...
Blood gas tension refers to the partial pressure of gases in blood. [1] There are several significant purposes for measuring gas tension. [ 2 ] The most common gas tensions measured are oxygen tension (P x O 2 ), carbon dioxide tension (P x CO 2 ) and carbon monoxide tension (P x CO). [ 3 ]
It is a major health problem, with one large review stating an incidence of 7.6% with an associated in hospital mortality rate of 11.9%. [2] Generally, pulmonary edema is associated with a poor prognosis with a 50% survival rate at one year, and 85% mortality at six years.
This helps to determine the degree of any problems with how the lungs transfer oxygen to the blood. [5] A sample of arterial blood is collected for this test. [6] With a normal P a O 2 of 60–100 mmHg and an oxygen content of F I O 2 of 0.21 of room air, a normal P a O 2 /F I O 2 ratio ranges between 300 and 500 mmHg.