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PCBs may play a role in the development of cancers of the immune system because some tests of laboratory animals subjected to very high doses of PCBs have shown effects on the animals' immune system, and some studies of human populations have reported an association between environmental levels of PCBs and immune response.
Because current human evidence is incomplete, there is only data suggesting the carcinogenic effects of PCBs in humans. [15] While little research has been done on the toxic effects of 2,2’,3,3’,4,4’-hexachlorobiphenyl, PCBs have been found to cause irritation in the eyes and when inhaled also in the airways.
Ortho-PCBs may alter hormone regulation through disruption of the thyroid hormone transport by binding to transthyretin. [8] Coplanar PCBs are similar to dioxins and furans, both bind to the aryl hydrocarbon receptor (AhR) in organisms and may exert dioxin-like effects, in addition to the effects shared with non-coplanar PCBs.
Immediate effects of PCB exposure include pigmentation of nails and mucous membranes and swelling of the eyelids, along with fatigue, nausea, and vomiting. Effects are transgenerational, as the chemical can persist in a mother's body for up to 7 years, resulting in developmental delays and behavioral problems in her children. Food contamination ...
PCB contamination in humans may come from drinking the contaminated water, absorption through the skin, eating contaminated aquatic life, and/or inhaling volatilized PCBs. PCB contamination is especially dangerous for pregnant and nursing women. The contamination can reach the fetus and potentially cause birth defects.
No harmful levels of carcinogenic PCBs were found inside the missile launch facilities at F.E. Warren Air Force base in Wyoming, the service said Tuesday, as it looks for possible causes for ...
Early studies on the effects of PBBs on human beings concerned the people in Michigan, United States who consumed PBB-contaminated animal products (see history of PBBs below). [3] A study of 327 girls aged 5–24 years in Michigan found those who were exposed in utero to PBBs at or above a level of 7 ppb found had an earlier age at menarche ...
PCB is suspected of having certain effects on liver and skin of humans. They are also suspected of causing cancer as well. EPA "estimates that 150 million pounds of PCBs are dispersed throughout the environment, including air and water supplies; an additional 290 million pounds are located in landfills in this country."