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Cryptococcus neoformans is an encapsulated basidiomycetous yeast [1] belonging to the class Tremellomycetes and an obligate aerobe [2] that can live in both plants and animals. Its teleomorph is a filamentous fungus , formerly referred to Filobasidiella neoformans .
Cryptococcosis is a potentially fatal fungal infection of mainly the lungs, presenting as a pneumonia, and in the brain, where it appears as a meningitis. [4] [9] Coughing, difficulty breathing, chest pain and fever are seen when the lungs are infected. [5]
Cryptococcus gattii, formerly known as Cryptococcus neoformans var. gattii, is an encapsulated yeast found primarily in tropical and subtropical climates. Its teleomorph is Filobasidiella bacillispora , a filamentous fungus belonging to the class Tremellomycetes .
Flucytosine by mouth is used for the treatment of serious infections caused by susceptible strains of Candida or Cryptococcus neoformans.It can also be used for the treatment of chromomycosis (chromoblastomycosis), if susceptible strains cause the infection.
Further research conducted at the Albert Einstein College of Medicine showed that three melanin-containing fungi—Cladosporium sphaerospermum, Wangiella dermatitidis, and Cryptococcus neoformans—increased in biomass and accumulated acetate faster in an environment in which the radiation level was 500 times higher than in the normal environment.
Cryptococcus is a genus of fungi in the family Cryptococcaceae that includes both yeasts and filamentous species. The filamentous, sexual forms or teleomorphs were formerly classified in the genus Filobasidiella , while Cryptococcus was reserved for the yeasts.
Cryptococcus species (cryptococcus gatti and neoformans) have a polysaccharide capsule surrounding the yeasts to shield the yeast from immune system killing. Cryptococcus also has a cell wall laccase , a copper-containing cell wall enzyme that increases the release of dopamine and prostaglandin E2 inflammatory markers in humans to increase ...
The majority of Cryptococcus species live in the soil and do not cause disease in humans. Cryptococcus neoformans is the major human and animal pathogen. Papiliotrema laurentii and Naganishia albida, both formerly referred to Cryptococcus, have been known to occasionally cause moderate-to-severe disease in human patients with compromised immunity.