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Most Pax genes contain a homeobox and a paired domain that also binds DNA to increase binding specificity, though some Pax genes have lost all or part of the homeobox sequence. [46] Pax genes function in embryo segmentation, nervous system development, generation of the frontal eye fields, skeletal development, and formation of face structures.
Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals. Hox proteins encode and specify the characteristics of 'position', ensuring that the correct structures form in the correct places of the body. For example, Hox genes in insects specify ...
Hox genes are found in bilateral animals, including Drosophila (in which they were first discovered) and humans. Hox genes are a subset of the homeobox genes. The Hox genes are often conserved across species, so some of the Hox genes of Drosophila are homologous to those in humans. In general, Hox genes play a role of regulating expression of ...
Paralogous genes can shape the structure of whole genomes and thus explain genome evolution to a large extent. Examples include the Homeobox genes in animals. These genes not only underwent gene duplications within chromosomes but also whole genome duplications. As a result, Hox genes in most vertebrates are clustered across multiple ...
3209 15398 Ensembl ENSG00000106031 ENSMUSG00000038203 UniProt P31271 Q62424 RefSeq (mRNA) NM_000522 NM_008264 RefSeq (protein) NP_000513 NP_032290 Location (UCSC) Chr 7: 27.19 – 27.2 Mb Chr 6: 52.23 – 52.24 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-A13 is a protein that in humans is encoded by the HOXA13 gene. Function In vertebrates, the genes encoding ...
For gene duplication events, if a gene in an organism is duplicated, the two copies are paralogous. They can shape the structure of whole genomes and thus explain genome evolution to a large extent. Examples include the Homeobox genes in animals. These genes not only underwent gene duplications within chromosomes but also whole genome ...
Homeotic selector genes encode regulatory DNA-binding proteins which are all related through a highly conserved DNA binding sequences called the homeobox (from which the "Hox Complex" name is derived from). Although each all of the DNA-binding complexes are conserved, each para-segment still has an individual identity.
Figure 1 - Mutations in the Ubx gene lead to transformation of appendages in T2 and T3 segments, resulting in a second set of wings observed in the "bithorax" phenotype. Ultrabithorax (Ubx) is a homeobox gene found in insects, and is used in the regulation of patterning in morphogenesis.