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Mitochondrial uncoupling protein 3 is a protein that in humans is encoded by the UCP3 gene. [ 5 ] [ 6 ] The gene is located in chromosome (11q13.4) with an exon count of 7 (HGNC et al., 2016) and is expressed on the inner mitochondrial membrane .
Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. [ 5 ] [ 6 ] This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis, [ 7 ] [ 8 ] [ 9 ] and small, round mitochondria. [ 10 ]
NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)]. [5] [6] SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.
The gene has 9 exons and produces a 40.1 kDa protein composed of 362 amino acids. [10] [11] [9] The encoded protein (PHC) is a multi-pass transmembrane protein located in the mitochondrial inner membrane; it contains six transmembrane segments, emerging into a large extramembranous loop.
68349 Ensembl ENSG00000213619 ENSG00000285387 ENSMUSG00000005510 UniProt O75489 Q9DCT2 RefSeq (mRNA) NM_004551 NM_026688 RefSeq (protein) NP_004542 NP_080964 Location (UCSC) Chr 11: 47.57 – 47.58 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial is an enzyme that in humans is encoded by the NDUFS3 gene on ...
DAP3 is a 28S subunit protein of mitoribosomes and localizes to the mitochondrial matrix. [7] [8] [9] As part of the mitoribosome, DAP3 participates in the translation of the 13 ETC complex proteins encoded in the mitochondrial genome, and consequently, in the regulation of cellular respiration.
Trifunctional enzyme subunit beta, mitochondrial (TP-beta) also known as 3-ketoacyl-CoA thiolase, acetyl-CoA acyltransferase, or beta-ketothiolase is an enzyme that in humans is encoded by the HADHB gene. [5] HADHB is a subunit of the mitochondrial trifunctional protein and has thiolase activity.
Dynamin-1-like protein is a GTPase that regulates mitochondrial fission. In humans, dynamin-1-like protein, which is typically referred to as dynamin-related protein 1 (Drp1), is encoded by the DNM1L gene and is part of the dynamin superfamily (DSP) family of proteins. [5] [6] [7]
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