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Emergent intramuscular dosing can be given if child is not tolerating oral medications or unable to get IV within 15 minutes. IM hydrocortisone sodium succinate doses are: [3] 25 mg for child 3 years and younger; 50 mg for children >3 yrs – 12 years; 100 mg for children 12 years and older.
[111] At low doses, breast tenderness has been reported in only 5% of women, but at high doses, it has been reported in up to 40% of women. [130] [63] Breast enlargement and tenderness may occur in 26% of women at high doses. [86] Some women regard spironolactone-induced breast enlargement as a positive effect. [64]
If high doses were used for six to 10 days, reduce to replacement dose immediately and taper over four more days. Adrenal recovery can be assumed to occur within two to four weeks of completion of steroids. If high doses were used for 11–30 days, cut immediately to twice replacement, and then by 25% every four days.
Methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol) is a synthetic glucocorticoid, primarily prescribed for its anti-inflammatory and immunosuppressive effects. [4] [5] [6] It is either used at low doses for chronic illnesses or used concomitantly at high doses during acute flares.
It can be divided in several doses or administered as a continuous infusion. [1] Fludrocortisone is optional in CIRCI, and dexamethasone is not recommended. [4] Little evidence is available to judge when and how corticosteroid therapy should be stopped; guidelines recommend tapering corticosteroids when vasopressors are no longer needed. [1] [4]
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While the evidence for corticosteroids causing peptic ulceration is relatively poor except for high doses taken for over a month, [32] the majority of doctors as of 2010 still believe this is the case, and would consider protective prophylactic measures. [33] Eyes: chronic use may predispose to cataract and glaucoma.
Drostanolone propionate produces considerably less virilization in women compared to equal doses of testosterone propionate. [1] However, since the given dosage for breast cancer was relatively high (200 mg/twice a week), [ 8 ] mild virilization including oily skin , acne , voice deepening , hirsutism , and clitoral enlargement could still ...