Search results
Results from the WOW.Com Content Network
D-dimer (or D dimer) is a dimer that is a fibrin degradation product (FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two D fragments of the fibrin protein joined by a cross-link , hence forming a protein dimer .
Principles of D-dimer testing. Fibrin degradation products (FDPs), also known as fibrin split products, are components of the blood produced by clot degeneration. [1] Clotting, also called coagulation, at the wound site produces a mass of fibrin threads called a net that remains in place until the cut is healed.
Dimer may refer to: Dimer (chemistry), a chemical structure formed from two similar sub-units Protein dimer, a protein quaternary structure; d-dimer; TH-dimer;
Findings may include low platelets, low fibrinogen, high INR, or high D-dimer. [2] Treatment is mainly directed towards the underlying condition. [2] [3] Other measures may include giving platelets, cryoprecipitate, or fresh frozen plasma. [2] Evidence to support these treatments, however, is poor. [2] Heparin may be useful in the slowly ...
In chemistry, dimerization is the process of joining two identical or similar molecular entities by bonds.The resulting bonds can be either strong or weak. Many symmetrical chemical species are described as dimers, even when the monomer is unknown or highly unstable.
Low clinical probability. If negative D-dimer, PE is excluded. If positive D-dimer, obtain MDCT and base treatment on results. Moderate clinical probability. If negative D-dimer, PE is excluded. However, the authors were not concerned that a negative MDCT with negative D-dimer in this setting has a 5% probability of being false. Presumably, the ...
Antibody-antigen technology can measure FDPs and a specific FDP, the D-dimer. This is more specific than the TCT, and confirms that fibrinolysis has occurred. It is therefore used to indicate deep-vein thrombosis, pulmonary embolism, DIC, and efficacy of treatment in acute myocardial infarction.
In European Americans, 2% of the variation in D-dimer levels is due to polymorphisms in various fibrinolysis-related genes such as fibrinogen, PAI-1 and plasminogen. In African Americans the sample was too small to establish any linkage. Fibrinogen mutations, in particular, explained D-dimer levels >20% higher than controls.