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D-dimer (or D dimer) is a dimer that is a fibrin degradation product (FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two D fragments of the fibrin protein joined by a cross-link , hence forming a protein dimer .
It is regarded as a highly sensitive and specific test for pulmonary embolism. [1] CTPA is typically only requested if pulmonary embolism is suspected clinically. If the probability of PE is considered low, a blood test called D-dimer may be requested. If this is negative and risk of a PE is considered negligible, then CTPA or other scans are ...
The purpose of the rule is to select the best method of investigation (e.g. D-dimer testing, CT angiography) for ruling in or ruling out the diagnosis of PE, and to improve the interpretation and accuracy of subsequent testing, based on a Bayesian framework for the probability of the diagnosis.
D-dimer is highly sensitive but not specific (specificity around 50%). In other words, a positive D-dimer is not synonymous with PE, but a negative D-dimer is, with a good degree of certainty, an indication of absence of a PE. [52] A low pretest probability is also valuable in ruling out PE. [53]
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A D-dimer test can also be used to assist with excluding the diagnosis or to signal a need for further testing. [5] Diagnosis is most commonly confirmed by ultrasound of the suspected veins. [5] VTE becomes much more common with age. The condition is rare in children, but occurs in almost 1% of those ≥ age 85 annually. [3]
A Minnesota couple has reportedly been sentenced to four years after they locked their children in cages for "their safety." The couple was arrested and charged with 16 counts in June 2023. They ...
It published a photo of Tamaki in a grey hoodie as he emerged from a bar, followed 20 minutes later by the woman. "My wife had told me, 'you can't protect the country if you can't protect the ...