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[98] [99] The metabolic clearance rates and hence blood half-lives of estrogen conjugates like estrone sulfate are much longer than those of estradiol and estrone. [ 10 ] [ 12 ] [ 91 ] Estrogen conjugates, primarily estrone sulfate, serve as a large circulating reservoir for estradiol, and because of this, they function to greatly extend the ...
Estradiol is an estrogen, or an agonist of the nuclear estrogen receptors (ERs), the estrogen receptor alpha (ERα) and the estrogen receptor beta (ERβ). [1] [2] [6] In one study, the EC 50 Tooltip half-maximal effective concentration value of estradiol for the human ERα was 50 pM (0.05 nM) and for the human ERβ was 200 pM (0.2 nM).
Hypoestrogenism, or estrogen deficiency, refers to a lower than normal level of estrogen. It is an umbrella term used to describe estrogen deficiency in various conditions. Estrogen deficiency is also associated with an increased risk of cardiovascular disease, [1] and has been linked to diseases like urinary tract infections [2] and osteoporosis.
This weight gain can increase your risk of obesity, hypertension (high blood pressure), high cholesterol, and other weight-related conditions like insulin resistance, type 2 diabetes, and heart ...
Like other blood pressure drugs, it can cause side effects including dizziness, lightheadedness and headaches. In older women taking it, or those with certain medical conditions, potassium levels ...
A 2021 study found that yogurt could help reduce blood pressure due to its high concentration of micronutrients calcium, magnesium and potassium, which are all associated with a lower risk of ...
GPER is expressed in the blood vessel endothelium and is responsible for vasodilation and as a result, blood pressure lowering effects of 17β-estradiol. [49] GPER also regulates components of the renin–angiotensin system , which also controls blood pressure, [ 50 ] [ 51 ] and is required for superoxide-mediated cardiovascular function and aging.
The Estradiol blood test measures the amount of estradiol in the blood. [77] It is used to check the function of the ovaries, placenta, adrenal glands. [ 77 ] This can detect baseline estrogen in women with amenorrhea or menstrual dysfunction, and to detect the state of hypoestrogenicity and menopause.